|
KMID : 0882419930440020155
|
|
Korean Journal of Medicine
1993 Volume.44 No. 2 p.155 ~ p.162
|
|
|
Pulmonary Function Test and neutrophil Chemiluminescence in Asymptomatic Young Smokers
|
|
송정섭
권순석/김영균/김관형/한기돈/문화식/박성학
|
|
|
Abstract
|
|
|
ackground : Cigarette smoking is firmly established as the primary environmental
risk factor associated with chronic obstructive pulmonary disease (COPD) including pulmonary
emphysema and chronic bronchitis. The development of COPD is known to be preceeded
by small airway obstructive disease. Cigarette smoking induces lung phagocyte (macrophage
and neutrophils) recruitment, and that neutrophil and macrophage have increased oxidative
function in cigarette smokers. So we have investigated the possible relationship between
neutrophil activation and spirometric parameters in asymptomatic young smokers.
Methods : Oxidant generation by circulating neutrophils were measured by luminol
enhanced chemiluminescence (LECL) and lung function test were performed at the same
day in 24 asymptomatic young smokers and 24 non-smokers.
Results :
1) LECL of the peripheral blood neutrophils were significantly increased in smokers during
both in nonstimulated cases and in stimulated cases with phorbol myristate acetate (PMA)
than in non-smokers.
2) In pulmonary function test, Vmax75/FVC was significantly lower and FVC was
higher in smokers than in non-smokers.
3) In 4 smokers of those whose more than three spirometric parameters were below
85% predicted, there was a inverse relationship between PMA-activated neutrophil LECL
and FEF25 75%, Vmax 50/FVC, Vmax 75/FVC.
Conclustion : Our findings indicate that cigarette smoking can increase the reactive
oxidants from both non-stimulated and PMA stimulated peripheral blood neutrophils and
this increased LECL appears to be associated with small airway obstruction in some cases.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|